"The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID". SEM cells were injected into the tail vein and engraftment was monitored by flow cytometry. "Interleukin-12 dependent interferon-g production by CD8a + lymphoid dendritic cells". The efficacy of resveratrol as a preventive agent against the growth of t(4 11) acute lymphoblastic leukemia (ALL) was evaluated in NOD.CB17-Prkdcscid/J mice engrafted with the human t(4 11) ALL SEM cell line. doi: 10.1182/blood.V87.3.956.bloodjournal873956. mamoru ito and his group at the laboratory animal research department in ciea were successful in establishing an extremely severe combined immunodeficient mouse called the nog (nod/shi-scid,il-2rnull) mouse (ito m et al. "Modulation of hematopoiesis in mice with a truncated mutant of the interleukin-2 receptor gamma chain". "Lymphohaematopoietic abnormalities and systemic lymphoproliferative disorder in interleukin-2 receptor gamma chain-deficient mice". SCID-Hu mice: scid mice that have been engrafted with. Tumor volume (Figure A) and body weight (Figure B) were measured at different time points. NOD-scid IL2rnull mice engraft at high levels with human cells: 10-90 human cells in periphery. 5×10 6 A549 human non-small cell lung carcinoma cells were injected subcutaneously into BALB/c nude mice or NOD scid mice. "DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect". Kinetics of Tumor growth and body weight in mice bearing A549 non-small cell lung carcinoma. "A severe combined immunodeficiency mutation in the mouse". "Breeding of a non-obese, diabetic strain of mice". The murine autoimmune diabetes model: NOD and related strains. "Multiple defects in innate and adaptive immunologic function in NOD/LtSz-scid mice". The Nonobese diabetic/severe combined immunodeficiency (NOD-SCID) mouse is an ideal animal model given its compatibility with xeno-transfusion. "NOD/SCID/γ null mouse: an excellent recipient mouse model for engraftment of human cells". Background: Measuring survival of human platelets following their circulation in the blood allows for investigations of function, clearance, and the impact of their treatment prior to infusion. Lack of NK cells, dendritic cell dysfunctions, and other unknown deficiencies due to inactivation of the IL-2Rγ gene.Lack of functional T and B cells that is derived from a mutation of protein kinase (Prkdc: protein kinase, DNA activated, catalytic polypeptide), which is the causative gene of the scid mutation.as autoimmune non-obese-type diabetes mice. The NOD/Shi inbred strain was first discovered by Makino et al. Reduced innate immunity derived from a NOD inbred strain, which involves a macrophage dysfunction, and a defect of complement hemolytic activity and reduced NK activity.NOG mouse has multiple immunodeficiencies that are principally derived from three strains of mice: 1) NOD/Shi inbred strain, 2) SCID, 3) IL-2Rγ null. No leakiness: no incidence of T, B cells with aging.No activity of T cell, B cell and NK cell.The NOG mouse was generated in CIEA in 2000 by back-cross mating of C57BL/6J-IL-2Rγ null mouse that was originally developed by Kazuo Sugamura, a professor of Tohoku University, to NOD/Shi- scid mouse that was developed in CIEA.
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